What are at least 3 factors to consider before prescribing a particular antibiotic to a patient?

Published by Jeannie R. Ferrell

Dec 8, 2022

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Study sources
The recommended reading for this week should be the main source you need. That is:
Open Education Resources
OpenStax Microbiology: Chapter 18.5: Vaccines (https://openstax.org/books/microbiology/pages/18-5-vaccines)
OpenStax Microbiology Chapter 14: Antimicrobial drugs(https://openstax.org/books/microbiology/pages/14-introduction)
Microbiology Chapter 20: Laboratory analysis of the immune system (https://openstax.org/books/microbiology/pages/20-introduction)
There may be specific questions/topics you want to do an internet search for and by now you should feel confident to identify trustworthy sources. I am always happy to help if you need more recommendations for sources or advice on whether a source is trustworthy.
Instructions
As always, all work must be your own, and any material copied from another source must be clearly identified and the source cited.
1. Vaccines
A – What are vaccines and how do they work?
Create at least half a page of writing, a page of original diagrams or a mixture of both.
Address each of the following:
How do vaccines work to create immunity to diseases?
What are vaccines typically made of?
B – Specific vaccination campaigns
Create at least half a page of writing, a page of original diagrams or a mixture of both.
Pick a specific vaccine, against a specific disease (e.g. the Pfizer vaccine against COVID-19).
Identify and study at least 3 reliable sources of information related to the vaccine and its use to tackle the disease.
List all 3 sources.
What is the disease and how is it caused by the pathogen?
What is the vaccine and how does it work to trigger immunity?
How effective has the vaccination campaign been? What factors made the campaign successful or limited its success?
2. Monoclonal antibodies
Create at least half a page of writing, a page of original diagrams or a mixture of both to address the following:
What are monoclonal antibodies
How are they produced?
What can they be used for (consider both immunotherapies and immunoassays). Describe a few examples in detail, rather than just producing a long list of named uses without any details.
3. Antimicrobial drugs
Pick 5 specific antimicrobial drugs (antibiotics, antivirals or antifungals).
For each one provide information on each of the following:
What is the name of the drug?
What specific molecule or biochemical process does it target in the pathogen?
What is it used to treat?
4. Antibiotic resistance
Imagine a bacterial pathogen.
There are 1000 bacterial cells inside patient X.
You have three antibiotics available for treatment: A, B and C.
The chance that any bacterial cell is resistant to A is 50%
The chance that any bacterial cell is resistant to B is 5%
The chance that any bacterial cell is resistant to C is 1%
4A – What is the probability that any given bacterial cell in patient X is resistant to A and B. Show your working
4B – What combination of antibiotics would you prescribe for this patient, and why?
4C – In general, why not just always give all patients as many different antibiotics as possible? What are at least 3 factors to consider before prescribing a particular antibiotic to a patient?

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